![]() The study incorporated ctDNA results up to five years after patients initiated osimertinib therapy.Ĭumulatively, the analysis indicated that EGFR C797X mutations were 1.25 times more common than MET amplification when osimertinib was used as first-line therapy and 2.4 times more common when it was used as second-line therapy. The analysis evaluated genomics data from the Guardant360 circulating tumor DNA (ctDNA) test for more than 2,000 patients who had any EGFR mutation and treatment with osimertinib, a third-generation EGFR TKI (tyrosine kinase inhibitor) and the current standard of care for patients with advanced-stage NSCLC with common EGFR mutations. “The analysis characterizes the increased frequency of EGFR C797X mutations as patients are treated with first-line osimertinib for longer durations, reinforcing the need for next-generation EGFR inhibitors to address C797X-driven resistance.”Ī collaborative effort between Guardant Health, Blueprint Medicines and Winship Cancer Institute, the study analyzed de-identified clinical and genomic data using the GuardantINFORM real-world evidence platform, which includes more than 65,000 adults with advanced NSCLC. “This real-world study improves our understanding of how resistance mutations to osimertinib emerge over time, with new insights on when EGFR C797X mutations overtake MET amplifications as the most commonly acquired resistance mechanism,” said Suresh Ramalingam, M.D., FACP, FASCO, executive director of Winship Cancer Institute of Emory University, who served as the principal investigator for the study. The results are being reported today at the International Association for the Study of Lung Cancer (IASLC) 2022 World Conference on Lung Cancer in Vienna. ![]() (Nasdaq: GH), a leading precision oncology company, and Blueprint Medicines Corporation (Nasdaq: BPMC) announced today they are presenting new data demonstrating that the EGFR C797X mutation is the most common resistance mechanism to osimertinib therapy for patients with advanced non-small cell lung cancer (NSCLC). PALO ALTO, Calif., & CAMBRIDGE, Mass.-(BUSINESS WIRE).
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